RDT MCQ A1 - Revision history

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{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal"
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|'''How well do RDT tests detect the different malaria species?'''
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The different malaria species are detected with different sensitivity. The table below provides an overall summary of the sensitivity that can be expected for RDT tests when suitable species-specific together with pan-malarial antibodies are used. The table is only a broad summary. Users are advised to understand the characteristics of the test they use including the merits of the antibodies employed in their test (see section below) 

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{| class="wikitable" style="border-style: solid; border-width: 4px; color:black"
!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|''' ''P.falciparum1 '''
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!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|At high parasitaemia expect high sensitivity (90-95%). This declines when parasite levels are lower (45-70%)2
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!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|''' ''P.vivax'' '''
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!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|Expect moderate to high sensitivity at high parasitaemia (70-90%). This declines markedly when parasite levels are lower (30-60%)2
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!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|''' ''P.ovale & P.malarae'' '''
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!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|Generally sensitivity is poor (approximately half the sensitivity shown for ''P.vivax'')
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!colspan="1" style = "background:#e1f1fd; border:solid; border-width: 3px;"|''' ''P.knowlesi''3 '''
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!colspan="1" style = "background:white; border:solid; border-width: 1px; color:black"|Reports suggest variable sensitivity that may depend on test used, RDTs are reported tp detect this species well when parasitaemia is high.
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Notes:
1 HRP2 mutation mean that in some geographical areas the diagnostic sensitivity may be significantly lower for HRP2-based tests (see below)
2 Low parasite number is considered as (<1000 parasites/μL) a level that may cause symptoms in children or non-immune travellers
3 There have been relatively few studies with this species so caution is required in RDT interpretation