https://haematologyetc.org/index.php?action=history&feed=atom&title=Prozone_effect_alt Prozone effect alt - Revision history 2026-11-05T15:06:56Z Revision history for this page on the wiki MediaWiki 1.41.1 https://haematologyetc.org/index.php?title=Prozone_effect_alt&diff=1029&oldid=prev Admin: Created page with "{{DISPLAYTITLE:<span style="position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);">{{FULLPAGENAME}}</span>}} ---- '''Navigation'''</br> <span style="font-size:90%">Main Malaria Index''</span></br> <span style="font-size:90%">>RDT main page''</span></br> <span style="font-size:90%">>>Multi Band Tests''</span></br> <span style="font-size:90%">>>>Curr..." 2024-10-30T13:17:24Z <p>Created page with &quot;{{DISPLAYTITLE:&lt;span style=&quot;position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);&quot;&gt;{{FULLPAGENAME}}&lt;/span&gt;}} ---- &#039;&#039;&#039;Navigation&#039;&#039;&#039;&lt;/br&gt; &lt;span style=&quot;font-size:90%&quot;&gt;<a href="/index.php?title=MalariaETC_Index" title="MalariaETC Index">Main Malaria Index</a>&#039;&#039;&lt;/span&gt;&lt;/br&gt; &lt;span style=&quot;font-size:90%&quot;&gt;&gt;<a href="/index.php?title=Rapid_diagnostic_tests_(RDTs)" title="Rapid diagnostic tests (RDTs)">RDT main page</a>&#039;&#039;&lt;/span&gt;&lt;/br&gt; &lt;span style=&quot;font-size:90%&quot;&gt;&gt;&gt;<a href="/index.php?title=Interpretation_guide:_MULTI_BAND_tests" title="Interpretation guide: MULTI BAND tests">Multi Band Tests</a>&#039;&#039;&lt;/span&gt;&lt;/br&gt; &lt;span style=&quot;font-size:90%&quot;&gt;&gt;&gt;&gt;Curr...&quot;</p> <p><b>New page</b></p><div>{{DISPLAYTITLE:&lt;span style=&quot;position: absolute; clip: rect(1px 1px 1px 1px); clip: rect(1px, 1px, 1px, 1px);&quot;&gt;{{FULLPAGENAME}}&lt;/span&gt;}}<br /> ----<br /> &#039;&#039;&#039;Navigation&#039;&#039;&#039;&lt;/br&gt;<br /> &lt;span style=&quot;font-size:90%&quot;&gt;[[MalariaETC Index|Main Malaria Index]]&#039;&#039;&lt;/span&gt;&lt;/br&gt;<br /> &lt;span style=&quot;font-size:90%&quot;&gt;&gt;[[Rapid diagnostic tests (RDTs)|RDT main page]]&#039;&#039;&lt;/span&gt;&lt;/br&gt;<br /> &lt;span style=&quot;font-size:90%&quot;&gt;&gt;&gt;[[Interpretation guide: MULTI BAND tests|Multi Band Tests]]&#039;&#039;&lt;/span&gt;&lt;/br&gt;<br /> &lt;span style=&quot;font-size:90%&quot;&gt;&gt;&gt;&gt;Current page: &#039;&#039;&#039;The prozone-like effect&#039;&#039;&#039;&lt;/span&gt;<br /> ----<br /> <br /> {| class=&quot;wikitable&quot; style=&quot;border-style: solid; border-width: 4px; border-color:green&quot;<br /> |colspan=&quot;1&quot; style = &quot;font-size:110%; color:blasck; background: FFFAFA&quot;|&lt;span style=&quot;color:navy&gt;&#039;&#039;&#039;The prozone-like (postzone) phenomenon&#039;&#039;&#039;&lt;/span&gt;<br /> <br /> <br /> The prozone-like or &quot;postzone&quot; phenomenon (the term postzone effect is preferred in this context as prozone refers to excess antibody, while postzone refers to excess antigen) is a very rare, but recognised effect that causes false negative results of tests. <br /> <br /> ----<br /> <br /> Most often the prozone effect is seen with HRP2 antigens. This effect means that where these is a &#039;&#039;&#039;very high parasitaemia&#039;&#039;&#039; (causing excess HRP2 antigen to be present) test can appear negative. It is thought that the presence of excess antigen means that the formation of appropriate antibody-antigen complexes is prevented so that the test does not function correctly.</div> Admin