Plasmodium LDH index - Revision history

Admin at 09:25, 17 December 2024

2024-12-17T09:25:06Z

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Admin at 11:40, 23 November 2024

2024-11-23T11:40:09Z

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	\|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"\|<span style="color:black>'''The species-~~specifis~~ forms of lactate dehyrogenase'''</span>		\|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"\|<span style="color:black>'''The species-specific forms of lactate dehyrogenase'''</span>

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Admin at 14:39, 20 November 2024

2024-11-20T14:39:09Z

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	<span style="font-size:90%">>[[~~MalariaETC~~ Index\|Back]]''</span></br>		<span style="font-size:90%">>[[Index\|Back]]''</span></br>

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Admin at 14:38, 20 November 2024

2024-11-20T14:38:23Z

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Admin: Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation'''
>Main Malaria Index''
>>RDT main page''
>>>RDT test antigens
>>>Current page: '''The H..."

2024-11-20T14:37:10Z

Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation''' >Main Malaria Index'' >>RDT main page'' >>>RDT test antigens >>>Current page: '''The H..."

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'''Navigation'''
>[[MalariaETC Index|Main Malaria Index]]''
>>[[Rapid diagnostic tests (RDTs)|RDT main page]]''
>>>[[RDT_test:_antigens|RDT test antigens]]
>>>Current page: '''The HRP2 antigen'''
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{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal"
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|'''The species-specifis forms of lactate dehyrogenase'''

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The malarial parasite forms of lactate dehydrogenase (pLDH) are specific forms of the LDH enzyme that is part of the malaria glycolytic pathway. pLDH is distinct from human forms of LDH allowing all parasite species to be identified by this LDH forms. However there are also species-specific forms that can be individually useful.'''P.falciparum-specific LDH''' (PfLDH). This form has very good sensitivity at high parasitaemia (exceeding 90%), althought at lower parasite levels (<1000 parasites/ μL) sensitivity of PfLDH may be less than that of HRP2 (around 45%). A potential advantage of PfLDH over HRP2 is that it is evolutionarily conserved antigen and does not have reported gene-delection mutants so may be an effective choice where malaria arises in ares with high rates of HRP2 deletion.'''P.vivax-specific LDH''' (PvLDH). This form has value for the specific diagnosis of ''P.vivax'' and may be useful in areas where this is a dominant species (e.g. areas of South America). PvLDH RDTs probably have similar sensitivity for P.vivax as the PpanLDH (of around 70-90% at high paraitaemia, declining when parasite levels are low - around 30-60%).

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'''Note''' LDH antgens are relatively rapidly cleared from the blood, so have potential value in testing response to treatment or for malaria testing in recently infected patients.

Plasmodium LDH index - Revision history

Admin at 09:25, 17 December 2024

Admin at 11:40, 23 November 2024

Admin at 14:39, 20 November 2024

Admin at 14:38, 20 November 2024

Admin: Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation''' >Main Malaria Index'' >>RDT main page'' >>>RDT test antigens >>>Current page: '''The H..."

Admin: Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- '''Navigation'''
>Main Malaria Index''
>>RDT main page''
>>>RDT test antigens
>>>Current page: '''The H..."