Histidine-rich protein 2 deletions index - Revision history

Admin at 09:24, 17 December 2024

2024-12-17T09:24:20Z

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Admin at 14:04, 21 November 2024

2024-11-21T14:04:12Z

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	\|colspan="1" style = "font-size:~~110~~%; color:black; background: FFFAFA"\|<span style="color:black>''' ''HRP2 gene'' deletion'''</span></br></br>		\|colspan="1" style = "font-size:130%; color:black; background: FFFAFA"\|<span style="color:black>''' ''HRP2 gene'' deletion'''</span></br></br>

	<span style="font-size:90%">Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing.</span>		<span style="font-size:90%">Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing.</span>

Admin at 14:03, 21 November 2024

2024-11-21T14:03:56Z

← Older revision		Revision as of 15:03, 21 November 2024
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	\|colspan="1" style = "font-size:~~140~~%; color:black; background: FFFAFA"\|<span style="color:black>''' ''HRP2 gene'' deletion'''</span>		\|colspan="1" style = "font-size:110%; color:black; background: FFFAFA"\|<span style="color:black>''' ''HRP2 gene'' deletion'''</span></br></br>

	<span style="font-size:90%">Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing.</span>		<span style="font-size:90%">Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing.</span>

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---- {| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal" |colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|Gene..."

2024-11-21T14:03:22Z

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{| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal"
|colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|''' ''HRP2 gene'' deletion'''

Gene-deletion mutations affecting ''HRP2'' and ''HRP3'' genes have been reported in South America, sub-Saharan Africa, and Asia, most likely though genetic selection of cases not detected by RDT testing.

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(1) Deletions of ''HRP2'' prevent its synthesis, causing reduced sensitivity (or sometimes entirely negative test results). In the presence of high parasitaemia HRP2 tests may still work even in the presence of single gene deletions of ''HRP2'' since the test also detects HRP3 protein.

(2) Note also the '''dual gene-deletions''' affecting both ''HRP2'' and ''HRP3'' genes are now recognised, and these cause fully negative test results.

The use of HRP to detect malaria may not be appropriate where the ''HRP2'' deletion rate is 5% or greater. Tests that combine ''HRP2'' with another antibody (either aldolase or pLDH) may help overcome these problems.

Histidine-rich protein 2 deletions index - Revision history

Admin at 09:24, 17 December 2024

Admin at 14:04, 21 November 2024

Admin at 14:03, 21 November 2024

Admin: Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- >>Back'' ---- {| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal" |colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|Gene..."

Admin: Created page with "{{DISPLAYTITLE:{{FULLPAGENAME}}}} ---- >>Back''
---- {| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; border-color:teal" |colspan="1" style = "font-size:140%; color:black; background: FFFAFA"|Gene..."