General and specific limitations of RDT tests - Revision history

Admin at 13:01, 21 November 2024

2024-11-21T13:01:46Z

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	\|colspan="1" style = "font-size:~~100~~%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>		\|colspan="1" style = "font-size:110%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>

Admin at 13:01, 21 November 2024

2024-11-21T13:01:19Z

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	\|colspan="1" style = "font-size:~~110~~%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>		\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>


	RDT evaluationby WHO requires tests to identify 75% of cases at parasite concentration of 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.		<span style="font-size:90%">RDT evaluationby WHO requires tests to identify 75% of cases at parasite concentration of 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.</br></br>These limitations are also summarised in the Table on the main page.</span>

	These limitations are also summarised in the Table on the main page.

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Admin at 15:08, 6 October 2024

2024-10-06T15:08:39Z

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	\|colspan="1" style = "font-size:~~100~~%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>		\|colspan="1" style = "font-size:110%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>

Admin at 15:04, 6 October 2024

2024-10-06T15:04:01Z

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Admin at 14:42, 26 September 2024

2024-09-26T14:42:53Z

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	RDT evaluationby WHO requires tests to identify 75% of cases at parasite concentration of 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.		RDT evaluationby WHO requires tests to identify 75% of cases at parasite concentration of 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.

			These limitations are also summarised in the Table on the main page.

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Admin at 13:27, 13 September 2024

2024-09-13T13:27:00Z

← Older revision		Revision as of 14:27, 13 September 2024
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	\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>		\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>

	RDT evaluationby WHO requires tests to identify 75% of cases ~~there are~~ 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.
			RDT evaluationby WHO requires tests to identify 75% of cases at parasite concentration of 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.

Admin at 13:26, 13 September 2024

2024-09-13T13:26:19Z

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	\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''~~Practical considerations~~ '''</span>		\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Detection limits of RDTs'''</span>

	RDT evaluationby WHO requires tests to identify 75% of cases there are 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.		RDT evaluationby WHO requires tests to identify 75% of cases there are 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.

Admin at 13:25, 13 September 2024

2024-09-13T13:25:49Z

← Older revision		Revision as of 14:25, 13 September 2024
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	\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Practical considerations '''</span>		\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Practical considerations '''</span>

	~~In the case of malarial RDTs, the~~ WHO requires ~~a panel detection score of~~ 75% ~~at a parasitaemia~~ of 200 parasites/μl ~~in order for the product to warrant endorsement~~. ~~[16] However, the threshold for pyrogenic onset has been shown to vary from 10~~ to ~~200,000 parasites/μl, with 22% of patients developing their first acute fever~~ at a parasite ~~load below 200/μl~~. ~~[75] Thus~~, ~~even~~ for the ~~select assortment~~ of ~~commercial malaria RDTs demonstrating compliance with WHO standards~~, ~~sufficiently low~~ limits of detection ~~have~~ not ~~been demonstrated for the early and accurate diagnosis of nascent infections, or of asymptomatic carriers~~.		RDT evaluationby WHO requires tests to identify 75% of cases there are 200 parasites/μl. It is important to note however that fevers may be present at lower parasite levels (particularly in non-immune travellers). Therefore, for the detection of ''P.falciparum'' using approved tests, the lower limits of detection are not sufficient to confidently exclude infection. For non-falciparum species tests are less reliable.

Admin at 13:12, 13 September 2024

2024-09-13T13:12:59Z

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			{\| class="wikitable" style="widthe:90%; border-style: solid; border-width: 4px; color:black"
			\|colspan="1" style = "font-size:100%; color:blasck; background: FFFAFA"\|<span style="color:navy>'''Practical considerations '''</span>

	In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards, sufficiently low limits of detection have not been demonstrated for the early and accurate diagnosis of nascent infections, or of asymptomatic carriers.		In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards, sufficiently low limits of detection have not been demonstrated for the early and accurate diagnosis of nascent infections, or of asymptomatic carriers.

Admin: Created page with "In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards,..."

2024-09-13T13:12:12Z

Created page with "In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards,..."

New page

In the case of malarial RDTs, the WHO requires a panel detection score of 75% at a parasitaemia of 200 parasites/μl in order for the product to warrant endorsement. [16] However, the threshold for pyrogenic onset has been shown to vary from 10 to 200,000 parasites/μl, with 22% of patients developing their first acute fever at a parasite load below 200/μl. [75] Thus, even for the select assortment of commercial malaria RDTs demonstrating compliance with WHO standards, sufficiently low limits of detection have not been demonstrated for the early and accurate diagnosis of nascent infections, or of asymptomatic carriers.