Biology of the gametocyte - Revision history

Admin at 11:02, 20 March 2025

2025-03-20T11:02:20Z

← Older revision		Revision as of 12:02, 20 March 2025
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	\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''		\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''
	\|}</br>		\|}</br>
	<span style="font-size:90%">Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).</br>		<span style="font-size:90%">Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).</br></br>

Admin at 11:01, 20 March 2025

2025-03-20T11:01:53Z

← Older revision		Revision as of 12:01, 20 March 2025
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	\|}		\|}
	</br>		</br>
	<span style="font-size:90%">Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>''' ''P.falciparum'' ''' In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).		<span style="font-size:90%">Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>''' ''P.falciparum'' '''</br>In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).
	<gallery mode="nolines" widths="150px" heights="150px" >		<gallery mode="nolines" widths="150px" heights="150px" >
	File:PFGc.jpg\|link={{filepath:PFGc.jpg}}		File:PFGc.jpg\|link={{filepath:PFGc.jpg}}

Admin at 11:01, 20 March 2025

2025-03-20T11:01:23Z

← Older revision		Revision as of 12:01, 20 March 2025
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	File:PFG4.jpg\|link={{filepath:PFG4.jpg}}		File:PFG4.jpg\|link={{filepath:PFG4.jpg}}
	</gallery></br></br>		</gallery></br></br>
	''' ''P.malariae'' '''		<span style="font-size:90%">''' ''P.malariae'' '''</br>Like other stages in this species the red cell containing the parasite is not enlarged or distorted and may be small. Parasites are typically small and neat with rounded form that do not fill the red cell.
	<~~span style="font-size:90%"~~>Like other stages in this species the red cell containing the parasite is not enlarged or distorted and may be small. Parasites are typically small and neat with rounded form that do not fill the red cell.
	<gallery mode="nolines" widths="150px" heights="150px" ></span>		<gallery mode="nolines" widths="150px" heights="150px" ></span>
	File:PMGc.jpg\|link={{filepath:PMGc.jpg}}		File:PMGc.jpg\|link={{filepath:PMGc.jpg}}
	File:PMG1.jpg\|link={{filepath:PMG1.jpg}}		File:PMG1.jpg\|link={{filepath:PMG1.jpg}}
	</gallery></br></br>		</gallery></br></br>
	''' ''P.vivax'' '''		<span style="font-size:90%">''' ''P.vivax'' '''</br>Typically these are very enlarged (significantly larger than normal red cells) often retaining the irregular shape that devlelops in ''P.vivax'' during the trophozoite stage.</span>
	<~~span style="font-size:90%"~~>Typically these are very enlarged (significantly larger than normal red cells) often retaining the irregular shape that devlelops in ''P.vivax'' during the trophozoite stage.</span>
	</br><gallery mode="nolines" widths="150px" heights="150px" >		</br><gallery mode="nolines" widths="150px" heights="150px" >
	File:PVGc.jpg\|link={{filepath:PVGc.jpg}}		File:PVGc.jpg\|link={{filepath:PVGc.jpg}}
	File:PVG1.jpg\|link={{filepath:PVG1.jpg}}		File:PVG1.jpg\|link={{filepath:PVG1.jpg}}
	</gallery></br></br>		</gallery></br></br>
	''' ''P.ovale'' '''		<span style="font-size:90%">''' ''P.ovale'' '''</br>Like other species the gametocytes retain the species-specific features acquired during the late trophozoite phase, they may appear sightly enlarged, often ovoid, and have fimbriation.</span>
	<~~span style="font-size:90%"~~>Like other species the gametocytes retain the species-specific features acquired during the late trophozoite phase, they may appear sightly enlarged, often ovoid, and have fimbriation.</span>
	</br><gallery mode="nolines" widths="150px" heights="150px" >		</br><gallery mode="nolines" widths="150px" heights="150px" >
	File:POGc.jpg\|link={{filepath:POGc.gif}}		File:POGc.jpg\|link={{filepath:POGc.gif}}
	File:POG4.jpg\|link={{filepath:POG4.jpg}}		File:POG4.jpg\|link={{filepath:POG4.jpg}}
	</gallery></br>		</gallery></br>
	''' ''P.knowlesi'' '''		<span style="font-size:90%">''' ''P.knowlesi'' '''</br>These gametocytes tend to be small like ''P.malariae'' but less neat and well formed,
	<~~span style="font-size:90%"~~>These gametocytes tend to be small like ''P.malariae'' but less neat and well formed,
	</br><gallery mode="nolines" widths="150px" heights="150px" ></span>		</br><gallery mode="nolines" widths="150px" heights="150px" ></span>
	File:PKGc.jpg\|link={{filepath:PKGc.jpg}}		File:PKGc.jpg\|link={{filepath:PKGc.jpg}}
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	\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''		\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''
	\|}</br>		\|}</br>
	Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).		<span style="font-size:90%">Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).</br>

Admin at 10:59, 20 March 2025

2025-03-20T10:59:36Z

← Older revision		Revision as of 11:59, 20 March 2025
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	\|colspan="1" style = "font-size:100%; color:black; background: white"\|<span style="color:navy></span>		\|colspan="1" style = "font-size:100%; color:black; background: white"\|<span style="color:navy></span>

	</br>The gametocyte is the sexual form of the malarial parasite that may have either male or female form (a higher percentage are female). Generally male gametocytes (microgametocytes) are smaller then the more pale female form (macrogametocytes). Gemetocytes are effectively “dormant” when in human blood and only develop further when ingested by a mosquito (the temperature drop in the mosquito foregut rapidly activates them to a single female gamete or 8 male gametes (see section on re-infection of the mosquito).		<span style="font-size:90%"></br>The gametocyte is the sexual form of the malarial parasite that may have either male or female form (a higher percentage are female). Generally male gametocytes (microgametocytes) are smaller then the more pale female form (macrogametocytes). Gemetocytes are effectively “dormant” when in human blood and only develop further when ingested by a mosquito (the temperature drop in the mosquito foregut rapidly activates them to a single female gamete or 8 male gametes (see section on re-infection of the mosquito).
	</br></br>		</br></br></span>

	{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"		{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"
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	\|}		\|}
	</br>		</br>
	Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>		<span style="font-size:90%">Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>''' ''P.falciparum'' ''' In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).
	''' ''P.falciparum'' ''' In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).
	<gallery mode="nolines" widths="150px" heights="150px" >		<gallery mode="nolines" widths="150px" heights="150px" >
	File:PFGc.jpg\|link={{filepath:PFGc.jpg}}		File:PFGc.jpg\|link={{filepath:PFGc.jpg}}
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	</gallery></br></br>		</gallery></br></br>
	''' ''P.malariae'' '''		''' ''P.malariae'' '''
	Like other stages in this species the red cell containing the parasite is not enlarged or distorted and may be small. Parasites are typically small and neat with rounded form that do not fill the red cell.		<span style="font-size:90%">Like other stages in this species the red cell containing the parasite is not enlarged or distorted and may be small. Parasites are typically small and neat with rounded form that do not fill the red cell.
	<gallery mode="nolines" widths="150px" heights="150px" >		<gallery mode="nolines" widths="150px" heights="150px" ></span>
	File:PMGc.jpg\|link={{filepath:PMGc.jpg}}		File:PMGc.jpg\|link={{filepath:PMGc.jpg}}
	File:PMG1.jpg\|link={{filepath:PMG1.jpg}}		File:PMG1.jpg\|link={{filepath:PMG1.jpg}}
	</gallery></br></br>		</gallery></br></br>
	''' ''P.vivax'' '''		''' ''P.vivax'' '''
	Typically these are very enlarged (significantly larger than normal red cells) often retaining the irregular shape that devlelops in ''P.vivax'' during the trophozoite stage.		<span style="font-size:90%">Typically these are very enlarged (significantly larger than normal red cells) often retaining the irregular shape that devlelops in ''P.vivax'' during the trophozoite stage.</span>
	</br><gallery mode="nolines" widths="150px" heights="150px" >		</br><gallery mode="nolines" widths="150px" heights="150px" >
	File:PVGc.jpg\|link={{filepath:PVGc.jpg}}		File:PVGc.jpg\|link={{filepath:PVGc.jpg}}
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	</gallery></br></br>		</gallery></br></br>
	''' ''P.ovale'' '''		''' ''P.ovale'' '''
	Like other species the gametocytes retain the species-specific features acquired during the late trophozoite phase, they may appear sightly enlarged, often ovoid, and have fimbriation.		<span style="font-size:90%">Like other species the gametocytes retain the species-specific features acquired during the late trophozoite phase, they may appear sightly enlarged, often ovoid, and have fimbriation.</span>
	</br><gallery mode="nolines" widths="150px" heights="150px" >		</br><gallery mode="nolines" widths="150px" heights="150px" >
	File:POGc.jpg\|link={{filepath:POGc.gif}}		File:POGc.jpg\|link={{filepath:POGc.gif}}
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	</gallery></br>		</gallery></br>
	''' ''P.knowlesi'' '''		''' ''P.knowlesi'' '''
	These gametocytes tend to be small like ''P.malariae'' but less neat and well formed,		<span style="font-size:90%">These gametocytes tend to be small like ''P.malariae'' but less neat and well formed,
	</br><gallery mode="nolines" widths="150px" heights="150px" >		</br><gallery mode="nolines" widths="150px" heights="150px" ></span>
	File:PKGc.jpg\|link={{filepath:PKGc.jpg}}		File:PKGc.jpg\|link={{filepath:PKGc.jpg}}
	File:PKG1.jpg\|link={{filepath:PKG1.jpg}}		File:PKG1.jpg\|link={{filepath:PKG1.jpg}}

Admin at 10:56, 20 March 2025

2025-03-20T10:56:23Z

← Older revision		Revision as of 11:56, 20 March 2025
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	File:PKG1.jpg\|link={{filepath:PKG1.jpg}}		File:PKG1.jpg\|link={{filepath:PKG1.jpg}}
	</gallery></br>		</gallery></br>
	~~</br>~~</br>		</br>
	{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"		{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"
	\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''		\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''
	\|}~~</br>~~</br>		\|}</br>
	Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).		Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).

Admin at 10:55, 20 March 2025

2025-03-20T10:55:55Z

← Older revision		Revision as of 11:55, 20 March 2025
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	File:POGc.jpg\|link={{filepath:POGc.gif}}		File:POGc.jpg\|link={{filepath:POGc.gif}}
	File:POG4.jpg\|link={{filepath:POG4.jpg}}		File:POG4.jpg\|link={{filepath:POG4.jpg}}
	</gallery~~></br~~></br>		</gallery></br>
	''' ''P.knowlesi'' '''		''' ''P.knowlesi'' '''
	These gametocytes tend to be small like ''P.malariae'' but less neat and well formed,		These gametocytes tend to be small like ''P.malariae'' but less neat and well formed,
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	File:PKGc.jpg\|link={{filepath:PKGc.jpg}}		File:PKGc.jpg\|link={{filepath:PKGc.jpg}}
	File:PKG1.jpg\|link={{filepath:PKG1.jpg}}		File:PKG1.jpg\|link={{filepath:PKG1.jpg}}
	</gallery~~></br~~></br>		</gallery></br>
	</br></br>		</br></br>
	{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"		{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"

Admin at 10:55, 20 March 2025

2025-03-20T10:55:28Z

← Older revision		Revision as of 11:55, 20 March 2025
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	File:PKG1.jpg\|link={{filepath:PKG1.jpg}}		File:PKG1.jpg\|link={{filepath:PKG1.jpg}}
	</gallery></br></br>		</gallery></br></br>
			</br></br>
	~~----~~

	{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"		{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"
	\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''		\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Relevance of gametocytes to clinical biology'''
	\|}		\|}</br></br>


	Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).		Following treatment of malaria these forms may persist (depending on the nature of the treatment) particularly in the first week but sometimes up to 28 days (unlike the asexual forms that generally disappear more rapidly).

Admin at 10:54, 20 March 2025

2025-03-20T10:54:33Z

← Older revision		Revision as of 11:54, 20 March 2025
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	\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Morphological features and relevance'''		\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Morphological features and relevance'''
	\|}		\|}
	~~</br>~~</br>		</br>
	Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>		Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>
	''' ''P.falciparum'' ''' In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).		''' ''P.falciparum'' ''' In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).

Admin at 10:54, 20 March 2025

2025-03-20T10:54:03Z

← Older revision		Revision as of 11:54, 20 March 2025
Line 20:		Line 20:
	\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Morphological features and relevance'''		\|colspan="1" style = "font-size:100%; color:black; background: gainsboro \|'''Morphological features and relevance'''
	\|}		\|}
			</br></br>
	Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>		Gametocytes (like schizonts) are the final mature form of parasites in the blood, consequently they have metabolised most or all of the red cell haemoglobin in order to grow. The red cell therefore simply consistes of membrane/cytoskeleton that surrounds the parasite without any of the red haemoglobin pigment generally with prominent malaria pigment (the metabolised haem molecule containing iron). The appearance of gametocytes however does vary according to species and this can aid morphological species identification</br></br>
	''' ''P.falciparum'' ''' In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).		''' ''P.falciparum'' ''' In this species the gametocytes have a "rod" shape which may be constricted by the remaining red cell membrane to form a curved shape (often described as banana-shaped).

Admin at 10:53, 20 March 2025

2025-03-20T10:53:34Z

← Older revision		Revision as of 11:53, 20 March 2025
Line 15:		Line 15:

	</br>The gametocyte is the sexual form of the malarial parasite that may have either male or female form (a higher percentage are female). Generally male gametocytes (microgametocytes) are smaller then the more pale female form (macrogametocytes). Gemetocytes are effectively “dormant” when in human blood and only develop further when ingested by a mosquito (the temperature drop in the mosquito foregut rapidly activates them to a single female gamete or 8 male gametes (see section on re-infection of the mosquito).		</br>The gametocyte is the sexual form of the malarial parasite that may have either male or female form (a higher percentage are female). Generally male gametocytes (microgametocytes) are smaller then the more pale female form (macrogametocytes). Gemetocytes are effectively “dormant” when in human blood and only develop further when ingested by a mosquito (the temperature drop in the mosquito foregut rapidly activates them to a single female gamete or 8 male gametes (see section on re-infection of the mosquito).
	~~----~~		</br></br>

	{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"		{\| class="wikitable" style="border-style: none; border-width: 2px; border-color: gainsboro; color:black"